Moderna and Pfizer vaccines prepare T cells to fight variants: study
Researchers have found that T cells from people who have recovered from Covid-19, or received Moderna or Pfizer-BioNTech vaccines, are still able to recognize several worrisome variants of SARS-CoV-2. Their study was published in Cell Reports Medicine. He found that “helper” T cells and “killer” T cells can still recognize mutated forms of the virus.
The study includes data on four popular variants – Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1) and Epsilon (B.1.427 / B.1.429). The Delta variant became prevalent after the study began, according to the La Jolla Institute of Immunology (LJI) website. He said ongoing studies have been extended to more variants, including Delta.
The researchers analyzed T cells from three different groups: people cured of Covid-19, people who had received the Moderna or Pfizer-BioNTech vaccine, and people never exposed to SARS-CoV-2 (from samples taken before the pandemic). The researchers tested T cell responses against Alpha, Beta, Gamma, and Epsilon. They found that both vaccinated individuals and recovered patients had cross-reacting T cells that could target these variants.
“With this study, the underlying message is optimistic…. When it comes to the T cell response, your immune system is still able to recognize these new variants and your T cells will be able to respond, ”studies first author Alison Tarke, PhD student at the University of Genoa and guest at Sette Lab at LJI, is quoted as saying.
Source: v Institute of Immunology of La Jolla