Asuncion M, Calvo RM, San Millan JL, Sancho J, Avila S, Escobar-Morreale HF. A prospective study of the prevalence of polycystic ovary syndrome in unselected Caucasian women from Spain. J Clin Endocrinol Metab. 2000;85(7):2434–8.

CAS PubMed Google Scholar

Azziz R, Woods KS, Reyna R, Key TJ, Knochenhauer ES, Yildiz BO. The prevalence and characteristics of polycystic ovary syndrome in an unselected population. J Clin Endocrinol Metab. 2004;89(6):2745–9.

CAS Google Scholar Article

March WA, Moore VM, Willson KJ, Phillips DI, Norman RJ, Davies MJ. The prevalence of polycystic ovary syndrome in a community sample assessed using contrasting diagnostic criteria. Hum Repr. 2010;25(2):544–51.

Google Scholar article

Esmaeilinezhad Z, Barati-Boldaji R, Brett N, de Zepetnek J, Bellissimo N, Babajafari S, et al. The effect of synbiotic pomegranate juice on cardiovascular risk factors in patients with PCOS: a randomized, triple-blind controlled trial. J Endocrinol Investig. 2020;43(4):539–48.

CAS Google Scholar Article

Banaszewska B, Wrotyńska-Barczyńska J, Spaczynski RZ, Pawelczyk L, Duleba AJ. Effects of resveratrol on polycystic ovary syndrome: a double-blind, randomized, placebo-controlled trial. J Clin Endocrinol Metab. 2016;101(11):4322–8.

CAS Google Scholar Article

Deeks AA, Gibson-Helm ME, Teede HJ. Anxiety and depression in polycystic ovary syndrome: an in-depth investigation. Fertil Sterile. 2010;93(7):2421–3.

Google Scholar article

D’Alterio MN, Sigilli M, Succu AG, Ghisu V, Laganà AS, Sorrentino F, et al. Pregnancy outcomes in women with polycystic ovary syndrome (PCOS). Minerva Obstet Gynecol. 2021.

Diamanti-Kandarakis E, Dunaif A. Insulin resistance and polycystic ovary syndrome revisited: an update on mechanisms and implications. Endocr Rev. 2012;33(6):981–1030.

CAS Google Scholar Article

Sirmans SM, Pate KA. Epidemiology, diagnosis and management of polycystic ovary syndrome. Clin Epidemiol. 2014;6:1.

Google Scholar

Taddei C, Zhou B, Bixby H, Carrillo-Larco RM, Jackson RT, Farzadfar F, et al. Repositioning of the global cholesterol epicenter not optimal. Nature. 2020;582:73–7.

Google Scholar article

Chiofalo B, Laganà AS, Palmara V, Granese R, Corrado G, Mancini E, et al. Fasting as a possible complementary approach for polycystic ovary syndrome: hope or hype? Medical assumptions. 2017; 105: 1–3.

Google Scholar article

Muscogiuri G, Palomba S, Laganà AS, Orio F. Current insights into inositol isoforms, Mediterranean and ketogenic diets for polycystic ovary syndrome: from bench to bedside. Curr Pharm Des. 2016;22(36):5554–7.

CAS Google Scholar Article

Laganà AS, Rossetti P, Buscema M, La Vignera S, Condorelli RA, Gullo G, et al. Metabolism and ovarian function in women with PCOS: a therapeutic approach with inositols. Int J Endocrinol. 2016;2016.

Paul C, Lagana AS, Maniglio P, Triolo O, Brady DM. Synergistic actions of inositol and other nutraceuticals counteract insulin resistance in polycystic ovary syndrome and metabolic syndrome: state of the art and future perspectives. Gynecol Endocrinol. 2016;32(6):431–8.

CAS Google Scholar Article

Schwalfenberg GK. Vitamins K1 and K2: The emerging group of vitamins necessary for human health. J Nutr Metab. 2017;2017.

Lee NK, Sowa H, Hinoi E, Ferron M, Ahn JD, Confavreux C, et al. Endocrine regulation of energy metabolism by the skeleton. Cell. 2007;130(3):456–69.

CAS Google Scholar Article

Vermeer’s resume. Vitamin K: the health effect beyond coagulation – an overview. Food Nutr Res. 2012;56(1):5329.

CAS Google Scholar Article

Shahrook S, Ota E, Hanada N, Sawada K, Mori R. Vitamin K supplementation during pregnancy to improve outcomes: a systematic review and meta-analysis. Sci Rep. 2018;8(1):1–11.

CAS Google Scholar Article

Ferland G. Vitamin K and the nervous system: an overview of its actions. Adv Nutr. 2012;3(2):204–12.

CAS Google Scholar Article

Gancheva SM, Zhelyazkova-Savova MD. Vitamin K2 improves anxiety and depression but not cognition in rats with metabolic syndrome: a role of blood sugar? Folia Med. 2016;58(4):264–72.

CAS Google Scholar Article

Fr DD, Tarlatzis R. 2003 Revised Consensus on Diagnostic Criteria and Long-Term Health Risks of Polycystic Ovary Syndrome. Fertil Sterile. 2004;81(1).

Rasekhi H, Karandish M, Jalali M, Mohammad-Shahi M, Zarei M, Saki A, et al. The effect of vitamin K1 supplementation on insulin sensitivity and resistance via osteocalcin in prediabetic women: a double-blind randomized controlled clinical trial. Eur J Clin Nutr. 2015;69(8):891.

CAS Google Scholar Article

Saghaei M. Random allocation software for parallel group randomized trials. Methodology BMC Med Res. 2004;4(1):26.

Google Scholar article

Tarkesh F, Namavar Jahromi B, Hejazi N, Tabatabaee H. Beneficial health effects of menaquinone-7 on body composition, glycemic indices, lipid profile and endocrine markers in patients with polycystic ovary syndrome. Food Sci Nutr. 2020;8(10):5612–21.

CAS Google Scholar Article

Karyani AK, Matin BK, Soltani S, Rezaei S, Soofi M, Salimi Y, et al. Socio-economic gradient of physical activity: results of the PERSIAN cohort study. BMC Public Health. 2019;19(1):1312.

Google Scholar article

Hagströmer M, Oja P, Sjöström M. The International Physical Activity Questionnaire (IPAQ): A Study of Concurrent and Constructive Validity. Public Health Nutr. 2006;9(6):755–62.

Google Scholar article

Mirghafourvand M, Charandabi SM-A, Aliasghari F. Predictors of depression in Iranian women with polycystic ovary syndrome. Common Mental Health J. 2018;54(8):1274–83.

Dokras A, Clifton S, Futterweit W, Wild R. Increased risk of abnormal depression scores in women with polycystic ovary syndrome: a systematic review and meta-analysis. Obstet Gynecol. 2011;117(1):145–52.

Google Scholar article

Peng Gj, Tian Js, Gao Xx, Zhou Yz, Qin Xm. Research on disease mechanism and drug treatment mechanism of depression. Curr Neuropharmacol. 2015;13(4):514–23.

CAS Google Scholar Article

Tsang CK, Kamei Y. Novel effect of vitamin K1 (phylloquinone) and vitamin K2 (menaquinone) on promoting nerve growth factor-mediated neurite outgrowth from PC12D cells. Neuroscience Lett. 2002;323(1):9–12.

CAS Google Scholar Article

Shirayama Y, Chen AC-H, Nakagawa S, Russell DS, Duman RS. Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression. J Neurosci. 2002;22(8):3251–61.

Siuciak JA, Lewis DR, Wiegand SJ, Lindsay RM. Antidepressant effect of brain-derived neurotrophic factor (BDNF). Pharmacol Biochem Behav. 1997;56(1):131–7.

CAS Google Scholar Article

Turker Y, Ekinozu I, Aytekin S, Turker Y, Basar C, Baltaci D, et al. Comparison of changes in the level of anxiety and depression between the use of dabigatran and warfarin in patients with atrial fibrillation. Clin Appl Thromb Hemost. 2017;23(2):164–7.

CAS Google Scholar Article

Rubio-López N, Morales-Suárez-Varela M, Pico Y, Livianos-Aldana L, Llopis-González A. Nutrient intake and symptoms of depression in Spanish children: the ANIVA study. Int J Environ Res Public Health. 2016;13(3):352.

Google Scholar article

Greenwood EA, Pasch LA, Cedars MI, Legro RS, Eisenberg E, Huddleston HG, et al. Insulin resistance is associated with a risk of depression in polycystic ovary syndrome. Fertil Sterile. 2018;110(1):27–34.

CAS Google Scholar Article

Manna P, Kalita J. Beneficial role of vitamin K supplementation on insulin sensitivity, glucose metabolism, and reduced risk of type 2 diabetes: a review. Nutrition. 2016;32(7–8):732–9.

CAS Google Scholar Article

Ferron M, Hinoi E, Karsenty G, Ducy P. Osteocalcin differentially regulates β-cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice. Proc Natl Acad Sci. 2008;105(13):5266–70.

CAS Google Scholar Article

Booth SL, Centi A, Smith SR, Gundberg C. The role of osteocalcin in human glucose metabolism: marker or mediator? Nat Rev Endocrinol. 2013;9(1):43–55.

CAS Google Scholar Article

Shahdadian F, Mohammadi H, Rouhani MH. Effect of vitamin K supplementation on glycemic control: a systematic review and meta-analysis of clinical trials. Horm Metab Res. 2018;50(03):227–35.

CAS Google Scholar Article

Choi HJ, Yu J, Choi H, An JH, Kim SW, Park KS, et al. Vitamin K2 supplementation improves insulin sensitivity via osteocalcin metabolism: a placebo-controlled trial. Diabetic treatments. 2011;34(9):e147-e.

Knapen M, Jardon K, Vermeer C. Vitamin K-induced effects on body fat and weight: results from a 3-year vitamin K2 intervention study. Eur J Clin Nutr. 2018;72(1):136–41.

CAS Google Scholar Article